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Tuesday, July 28, 2020 | History

2 edition of morphology of spray-dried particles. found in the catalog.

morphology of spray-dried particles.

David Edward Walton

morphology of spray-dried particles.

by David Edward Walton

  • 325 Want to read
  • 10 Currently reading

Published by Aston University. Department of Chemical Engineeringand Applied Chemistry in Birmingham .
Written in English


Edition Notes

Thesis (Phd) - Aston University, 1994.

ID Numbers
Open LibraryOL13907500M

The morphology of spray-dried protein particles was also affected by formulation. In protein:sugar formulations, spray-dried particles exhibited a smooth surface regardless of the protein-to-lactose ratio, whereas roughness was observed when mannitol was present at . They interpreted the factors that cause spray-dried particles to be sticky. In later research, King and his colleagues created a device to enable simultaneous measurement of particle morphology and loss of volatile components as the drying of single drops to particles took place. This research was supported by the National Science Foundation.

The spray dried particles ( mg) were dispersed in 10 mL of methanol and strongly homogenized with an ultraturrax homogenizer (IKA Labortechnik T25 Basic, Staufen im Breisgau, Germany) at 13, rpm for 3 min in order to break the particles. The suspension was left at 10 °C, in the dark, for 12 h. A novel combination of block copolymer (BCP) nano spray‐drying (NSD), solvent annealing, and selective metal oxide growth is utilized to create functional polymer nanoparticles, polymer‐metal‐oxide hybrid nanoparticles, and templated metal oxide nanoparticles with tunable composition, internal morphology.

The morphology and shape of zein-based particles prepared by the SAS process are also definitely better than aggregates and irregular or collapsed particles obtained up to now with the techniques commonly used in the pharmaceutical field, namely spray freeze-drying and spray-drying [,,]. The properties of spray dried particles namely morphology, surface characteristics, particle size, crystallinity, dissolution rate and compactibility were evaluated. Results: Spray drying process significantly changed the morphology of acetaminophen crystals from acicular (rod shape) to spherical microparticle.


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Morphology of spray-dried particles by David Edward Walton Download PDF EPUB FB2

The morphology of spray-dried particles a qualitative view Article (PDF Available) in Drying Technology 18(9) October with 1, Reads How we measure 'reads'. Structural categories of spray-dried particles are demonstrated and related to various drying mechanisms.

The methods of studying particle morphology are also. Morphology of Spray‐Dried Particles. Retention of Flavor in Spray‐Dried Food Products.

Encapsulation and Microencapsulation of Enzymes and Oil by Spray Drying. General Quality Aspects. Concluding Remarks. ReferencesCited by:   THE MORPHOLOGY OF SPRAY-DRIED PARTICLESThe Effect of Process Variables upon the Morphology ofSpray-dried Particles D.

WALTON and C. MUMFORD (MEMBER)Department of Chemical Engineering and Applied Chemistry, Aston University, UKS ingle particles were produced in a convective drying process analogous to spray drying,in which, different Cited by:   Journals & Books; Help Download PDF These differences were hypothesized to be due to differences in particle size and morphology, where the spray-dried powders had smaller particle size and more complex morphology than the milled HME powder.

et ation of X-ray microtomography for the characterisation of hollow polymer-stabilised Author: Alyssa Ekdahl, Deanna Mudie, David Malewski, David Malewski, Greg Amidon, Aaron Goodwin. Spray Drying. Spray drying is a constructive single-step operation used to produce dry and potentially respirable powders for pulmonary delivery of vaccines from liquid starting materials,64 It is an effective and efficient way of producing dry powder formulations suitable for inhalation, provides control over parameters such as particle size and morphology, and offers an advantage of.

As the morphology of spray dried aqueous mannitol solutions is strongly influenced by the scale of the used spray dryer or more correctly by the droplet size generated in the spray dryer the purpose of this work is to carefully study and morphology of spray-dried particles.

book the morphologies and underlying particle formation mechanisms on lab and pilot scale. The morphology obtained in spray drying was reproduced in the single-particle drying. The surface compositions were also similar, but higher levels of surface-active materials were found at the surface of the single particles as compared to the spray-dried particles.

The spray dried particles showed a particle size within the range of 5 to 10 micron and different morphologies (e.g. shriveled, spherical or inflated shapes). The methodology proposed has allowed the production of particles with different sizes and morphologies in a controlled manner.

Controlling the morphology of spray dried particles have been extensively studied. [13, 14] Vehring and co-workers proposed that particle formation process is mainly governed by two factors, the.

ABSTRACT Industrial and pilot plant spray-dried materials were obtained from various manufacturers and qualitatively examined in order to identify structural and morphological features. Three distinct categories of particle morphology were identified.

Namely, crystalline, skin forming and agglomerate. A number of unusual morphological phenomena were also noted Selected properties such as.

Therefore, spray-dried particles with required size and morphology might be prepared by adjusting the chitosan concentration in the precursor solution, with most uniformed and smooth particle.

The morphology of the spray-dried particles is directly related to drying conditions and the constituents of the encapsulating composition. The physicochemical properties of the material to be atomized in the spray-drying partially determine the drying behavior and particle morphology of the final product [ 68 ].

Littringer, E-M, Mescher, A, Schröttner, H, Walzl, P & Urbanetz, NATailoring particle morphology of spray dried mannitol carrier particles by variation of the outlet temperature.

in Annual Meeting of the Institute for Liquid Atomization and Spray Systems - Europe., pp. Annual Meeting of the Institute for Liquid Atomization and. Walton DE, Mumford CJ () The morphology of spray-dried particles.

The effect of process variables upon the morphology of spray-dried particles. Trans Inst Chem Eng – Article CAS Google Scholar Download references. Effect of various atomization methods and solute concentration on the morphology of spray dried magnesium sulphate particles is investigated.

Four types of atomizers are characterized and tested including (i) a vibrating mesh nebulizer, (ii) a splash plate nozzle, (iii) an air mist atomizer, and (iv) a pressure atomizer.

The morphology of spray-dried starch particles was evaluated by optical stereomicroscopy (Nikon SMZ stereo microscope, Tokyo, Japan). Samples of starch particles were dispersed, immediately after preparation, in cyclohexane, applied to a microscope slide, and examined microscopically.

The morphology of starch spray-dried particles was also. Physical Characteristics of Spray-Dried Particles. The surface morphology of spray-dried particles was characterised by SEM (Fig.

1a–c), which showed that the particle surfaces varied from smooth to moderately corrugated, and to raisin-like. The degree of surface corrugation of each sample was further quantified using AFM.

The organic solution advanced co-spray-dried tacrolimus lung surfactant mimic particles (Figure 3B and C) successfully formed with equivalent sphere particle morphology with a corrugated surface morphology, which are two essential particle properties for inhalation delivery of dry powders.

The particle size observed by SEM is in excellent. bacterial infection of the lung seems possible by spray dried particles. The key benefits of this technology are the possibilities to control the size and morphology of the particles. The fact that it is a very gentle method enables to spray dry even heat-sensitive.

Morphology of spray dried particles Skin-forming morphology with hollow internal structure Blow-hole formation Agglomerate Formation of dented structure and presence of small particles within large particles Spray-drying process parameters and their influence on product quality   Numerous reviews and book chapters have already been published on the subject of nano spray drying technology ArpagausThe nano spray dried particles ranged from to µm Most of the particles revealed a hollow morphology characterized by a distinct shell of mannitol and nanoparticles.Micrometric ordered mesoporous silica spheres are synthesised by spray-drying alcoholic sols.

For this synthetic route, the important effect of siloxane chemistry on both the morphological and the textural properties of spray-dried silica particles is demonstrated. This is achieved by correlating data obtained on the sols prior to atomisation (29 Si liquid state NMR, SAXS) with data coming.